Effects of ethanolic extract of mustard seed on kidney tissues of albino rats infected with candida SP
Enas Abd-El Hay Taha Tolba
Mustard seeds (Brassica species) are widely used as medicinal crops and spices. A study designed to investigate the possible renal protective effect of Mustard seed (MS) extract was assessed against induced candida infection in albino rats. Animals were divided into 4 groups, each of 5 rats. Control group receive distilled water by oral gavage; the second group treated with ethanolic extract of Mustard seed (500 mg/kg body weight) orally every day for 14 days. The third represents candida infected animals. The forth group represented the infected animals treated with mustard seed extract. Elevated serum renal biomarkers such as urea and creatinine were observed due to candida infection. Combined administration of mustard seed extract with candida infection to rat partially normalized the altered biochemical markers. Moreover, fungal infection caused histological changes in kidney of rat including cloudy swelling of renal tubules as well as, atrophied glomerulus. However, co-administration of mustard seed extract with infection alleviated to some extent the changes and the kidney structure and function return normal state. The results of this study strongly indicate that Mustard seed has possible potent renal protective action candida infection against in rats.